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TUBA1A (Tubulin alpha-1A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.55, animal model 0.55, genetic association 0.00, clinical 1.00).
In plain words · TUBA1A (Tubulin alpha-1A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
TUBA1A (Tubulin alpha-1A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
No product in this corpus aims at TUBA1A yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TUBA1A: RNA tissue enhanced (brain 2,690 nTPM); high antibody staining in 35 normal tissues; highest cancer staining head and neck cancer (4 of 4 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lung cancer (all types), Lymphoma, Prostate cancer, Cervical cancer, Multiple myeloma, Sarcomas (soft tissue, bone, GIST)); Open Targets associates it with 19 specific cancer types at or above 0.5 (breast cancer, non-small cell lung carcinoma, breast carcinoma, Hodgkins lymphoma, cervical cancer, plasma cell myeloma and more). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TUBA1A tissue; Open Targets ENSG00000167552 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: Cowan N.J. et al, Mol. Cell. Biol, 1983, "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Source.
Sources: HGNC HGNC:20766 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q71U36 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167552 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.54, prostate cancer 0.59, ovarian cancer 0.57, cervical cancer 0.59, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, flagellum axoneme (UniProt). Locus 12q13.12 (HGNC).
RNA: tissue enhanced (brain 2,690 nTPM), detected in all normal tissues.
Medium: Adipose tissue, Cerebellum, Kidney, Liver, Parathyroid gland, Smooth muscle, Spleen, Vagina.
RNA cancer enriched: Glioblastoma Multiforme 3,673 pTPM.
Medium only: pancreatic cancer.
HPA TUBA1A tissue · HPA TUBA1A pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TUBA1A" OR ABSTRACT:"TUBA1A" OR TITLE:"tubulin alpha 1a" OR ABSTRACT:"tubulin alpha 1a" OR TITLE:"Tubulin alpha-1A chain" OR ABSTRACT:"Tubulin alpha-1A chain" OR TITLE:"TUBA3" OR ABSTRACT:"TUBA3" OR TITLE:"B-ALPHA-1" OR ABSTRACT:"B-ALPHA-1" OR TITLE:"FLJ25113" OR ABSTRACT:"FLJ25113") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBA1A, not a curated reading list.