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TRPS1 (Zinc finger transcription factor Trps1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.25, animal model 0.57, genetic association 0.69).
In plain words · TRPS1 (Zinc finger transcription factor Trps1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
TRPS1 (Zinc finger transcription factor Trps1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development.
No product in this corpus aims at TRPS1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2000. Earliest sequence paper UniProt cites for the protein: Momeni et al, Nat. Genet, 2000, "Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I". Source.
Sources: HGNC HGNC:12340 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UHF7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104447 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: breast cancer 0.53 (GraphQL API, CC0))
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Location: Nucleus (UniProt). Locus 8q23.3 (HGNC).
Query for this target: (TITLE:"TRPS1" OR ABSTRACT:"TRPS1" OR TITLE:"transcriptional repressor GATA binding 1" OR ABSTRACT:"transcriptional repressor GATA binding 1" OR TITLE:"Zinc finger transcription factor Trps1" OR ABSTRACT:"Zinc finger transcription factor Trps1" OR TITLE:"GC79" OR ABSTRACT:"GC79") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRPS1, not a curated reading list.