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TRIP11 (Thyroid receptor-interacting protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.95, genetic association 0.00, somatic mutation 0.45). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma.
In plain words · TRIP11 (Thyroid receptor-interacting protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
TRIP11 (Thyroid receptor-interacting protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function.
No product in this corpus aims at TRIP11 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1995. Earliest sequence paper UniProt cites for the protein: Lee J.W. et al, Mol. Endocrinol, 1995, "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Source.
Sources: HGNC HGNC:12305 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15643 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100815 (association with cancer (MONDO_0004992) 0.67; (GraphQL API, CC0)); IntOGen TRIP11 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Location: Golgi apparatus, cis-Golgi network membrane; Cytoplasm, cytoskeleton; Endoplasmic reticulum-Golgi intermediate compartment membrane (UniProt). Locus 14q32.12 (HGNC).
Query for this target: (TITLE:"TRIP11" OR ABSTRACT:"TRIP11" OR TITLE:"thyroid hormone receptor interactor 11" OR ABSTRACT:"thyroid hormone receptor interactor 11" OR TITLE:"Thyroid receptor-interacting protein 11" OR ABSTRACT:"Thyroid receptor-interacting protein 11" OR TITLE:"CEV14" OR ABSTRACT:"CEV14" OR TITLE:"Trip230" OR ABSTRACT:"Trip230" OR TITLE:"GMAP-210" OR ABSTRACT:"GMAP-210") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIP11, not a curated reading list.