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TRIM27 (Zinc finger protein RFP) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy. Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.96).
In plain words · TRIM27 (Zinc finger protein RFP) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
TRIM27 (Zinc finger protein RFP) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy.
No product in this corpus aims at TRIM27 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1988. Earliest sequence paper UniProt cites for the protein: Takahashi et al, Mol. Cell. Biol, 1988, "Developmentally regulated expression of a human 'finger'-containing gene encoded by the 5' half of the ret transforming gene". Source.
Sources: HGNC HGNC:9975 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P14373 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000204713 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy. Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Location: Nucleus; Cytoplasm; Nucleus, PML body; Early endosome (UniProt). Locus 6p22.1 (HGNC).
Query for this target: (TITLE:"TRIM27" OR ABSTRACT:"TRIM27" OR TITLE:"tripartite motif containing 27" OR ABSTRACT:"tripartite motif containing 27" OR TITLE:"Zinc finger protein RFP" OR ABSTRACT:"Zinc finger protein RFP" OR TITLE:"RNF76" OR ABSTRACT:"RNF76") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM27, not a curated reading list.