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TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.96, genetic association 0.19, somatic mutation 0.80, animal model 0.67).
In plain words · TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.
No product in this corpus aims at TPM4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1985. Earliest sequence paper UniProt cites for the protein: MacLeod A.R. et al, Proc. Natl. Acad. Sci. U.S.A, 1985, "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Source.
Sources: HGNC HGNC:12013 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P67936 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167460 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Binds calcium. Plays a role in platelet biogenesis. Location: Cytoplasm, cytoskeleton (UniProt). Locus 19p13.12-p13.11 (HGNC).
Query for this target: (TITLE:"TPM4" OR ABSTRACT:"TPM4" OR TITLE:"tropomyosin 4" OR ABSTRACT:"tropomyosin 4" OR TITLE:"Tropomyosin alpha-4 chain" OR ABSTRACT:"Tropomyosin alpha-4 chain") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPM4, not a curated reading list.