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TPH2 (Tryptophan 5-hydroxylase 2) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates. Plays a crucial role in regulating mood, anxiety and sleep.
In plain words · TPH2 (Tryptophan 5-hydroxylase 2) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
TPH2 (Tryptophan 5-hydroxylase 2) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates.
No product in this corpus aims at TPH2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA not detected, which says where the protein sits but not whether the tumour differs from normal tissue. HPA TPH2: RNA not detected; high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Neuroendocrine tumours); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas TPH2 tissue; Open Targets ENSG00000139287 associations
First described 2003. Earliest sequence paper UniProt cites for the protein: Walther D.J. et al, Science, 2003, "Synthesis of serotonin by a second tryptophan hydroxylase isoform". Source.
Sources: HGNC HGNC:20692 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IWU9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000139287 (per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.53 (GraphQL API, CC0))
Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates. Plays a crucial role in regulating mood, anxiety and sleep. Locus 12q21.1 (HGNC).
RNA: not detected, not detected normal tissues.
Medium: Cerebral cortex.
No cancer sample stained medium or high.
HPA TPH2 tissue · HPA TPH2 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TPH2" OR ABSTRACT:"TPH2" OR TITLE:"tryptophan hydroxylase 2" OR ABSTRACT:"tryptophan hydroxylase 2" OR TITLE:"Tryptophan 5-hydroxylase 2" OR ABSTRACT:"Tryptophan 5-hydroxylase 2" OR TITLE:"FLJ37295" OR ABSTRACT:"FLJ37295") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPH2, not a curated reading list.