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TOP2B (DNA topoisomerase 2-beta) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Neuroendocrine tumours, Breast cancer and 1 more.
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.93, animal model 0.39, genetic association 0.45, clinical 0.98).
In plain words · TOP2B (DNA topoisomerase 2-beta) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Neuroendocrine tumours, Breast cancer and 1 more.
TOP2B (DNA topoisomerase 2-beta) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Neuroendocrine tumours, Breast cancer and 1 more.
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
No product in this corpus aims at TOP2B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TOP2B: RNA low tissue specificity; high antibody staining in 26 normal tissues; highest cancer staining carcinoid (3 of 3 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lung cancer (all types), Neuroendocrine tumours, Breast cancer (all types)); Open Targets associates it with 2 specific cancer types at or above 0.5 (small cell lung carcinoma, breast cancer). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TOP2B tissue; Open Targets ENSG00000077097 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Chung T.D. et al, Proc. Natl. Acad. Sci. U.S.A, 1989, "Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes". Source.
Sources: HGNC HGNC:11990 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q02880 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000077097 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: small cell lung carcinoma 0.56, neuroendocrine neoplasm 0.57, breast cancer 0.55, lung cancer 0.58 (GraphQL API, CC0))
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. Location: Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus (UniProt). Locus 3p24.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Breast, Bronchus, Colon, Endometrium, Liver, Ovary, Pancreas.
Medium only: head and neck cancer, testis cancer.
HPA TOP2B tissue · HPA TOP2B pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TOP2B" OR ABSTRACT:"TOP2B" OR TITLE:"DNA topoisomerase II beta" OR ABSTRACT:"DNA topoisomerase II beta" OR TITLE:"DNA topoisomerase 2-beta" OR ABSTRACT:"DNA topoisomerase 2-beta" OR TITLE:"top2beta" OR ABSTRACT:"top2beta" OR TITLE:"TOPIIB" OR ABSTRACT:"TOPIIB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TOP2B, not a curated reading list.