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TOE1 (Target of EGR1 protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.73, affected pathway 0.25, genetic association 0.77).
In plain words · TOE1 (Target of EGR1 protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
TOE1 (Target of EGR1 protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression.
No product in this corpus aims at TOE1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2003. Earliest sequence paper UniProt cites for the protein: De Belle et al, J. Biol. Chem, 2003, "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". Source.
Sources: HGNC HGNC:15954 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96GM8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132773 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing. Location: Nucleus, nucleolus; Nucleus speckle (UniProt). Locus 1p34.1 (HGNC).
Query for this target: (TITLE:"TOE1" OR ABSTRACT:"TOE1" OR TITLE:"target of EGR1, exonuclease" OR ABSTRACT:"target of EGR1, exonuclease" OR TITLE:"Target of EGR1 protein 1" OR ABSTRACT:"Target of EGR1 protein 1" OR TITLE:"hCaf1z" OR ABSTRACT:"hCaf1z" OR TITLE:"TOE-1" OR ABSTRACT:"TOE-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TOE1, not a curated reading list.