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TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.91, animal model 0.39, genetic association 0.65).
In plain words · TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation.
No product in this corpus aims at TNS1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2000. Earliest sequence paper UniProt cites for the protein: Chen et al, Biochem. J, 2000, "Molecular characterization of human tensin". Source.
Sources: HGNC HGNC:11973 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HBL0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000079308 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarisation and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton. Location: Cell surface; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 2q35 (HGNC).
Query for this target: (TITLE:"TNS1" OR ABSTRACT:"TNS1" OR TITLE:"tensin 1" OR ABSTRACT:"tensin 1" OR TITLE:"Tensin-1" OR ABSTRACT:"Tensin-1" OR TITLE:"DKFZp586K0617" OR ABSTRACT:"DKFZp586K0617" OR TITLE:"PPP1R155" OR ABSTRACT:"PPP1R155" OR TITLE:"MXRA6" OR ABSTRACT:"MXRA6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNS1, not a curated reading list.