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TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.93, animal model 0.48, genetic association 0.71).
In plain words · TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.
TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1.
No product in this corpus aims at TNFRSF13B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: von Buelow G.-U. et al, Science, 1997, "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily". Source.
Sources: HGNC HGNC:18153 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14836 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000240505 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: plasma cell myeloma 0.56 (GraphQL API, CC0))
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Location: Membrane (UniProt). Locus 17p11.2 (HGNC).
Query for this target: (TITLE:"TNFRSF13B" OR ABSTRACT:"TNFRSF13B" OR TITLE:"TNF receptor superfamily member 13B" OR ABSTRACT:"TNF receptor superfamily member 13B" OR TITLE:"Tumor necrosis factor receptor superfamily member 13B" OR ABSTRACT:"Tumor necrosis factor receptor superfamily member 13B" OR TITLE:"CD267" OR ABSTRACT:"CD267" OR TITLE:"IGAD2" OR ABSTRACT:"IGAD2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNFRSF13B, not a curated reading list.