Loading
TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.67).
In plain words · TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. Location: Endoplasmic reticulum membrane (UniProt).
No product in this corpus aims at TMEM238L yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:44356 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A6NJY4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000263429 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.53 (GraphQL API, CC0))
May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. Location: Endoplasmic reticulum membrane (UniProt). Locus 17p13.1-p12 (HGNC).
Query for this target: (TITLE:"TMEM238L" OR ABSTRACT:"TMEM238L" OR TITLE:"transmembrane protein 238 like" OR ABSTRACT:"transmembrane protein 238 like" OR TITLE:"Transmembrane protein 238-like" OR ABSTRACT:"Transmembrane protein 238-like" OR TITLE:"FORCP" OR ABSTRACT:"FORCP" OR TITLE:"LINC00675" OR ABSTRACT:"LINC00675") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TMEM238L, not a curated reading list.