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TMEM17 (Transmembrane protein 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signalling.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.68).
In plain words · TMEM17 (Transmembrane protein 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
TMEM17 (Transmembrane protein 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
No product in this corpus aims at TMEM17 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:26623 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86X19 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186889 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0))
Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signalling. Location: Cell projection, cilium membrane (UniProt). Locus 2p15 (HGNC).
Query for this target: (TITLE:"TMEM17" OR ABSTRACT:"TMEM17" OR TITLE:"transmembrane protein 17" OR ABSTRACT:"transmembrane protein 17" OR TITLE:"Transmembrane protein 17" OR ABSTRACT:"Transmembrane protein 17" OR TITLE:"FLJ34583" OR ABSTRACT:"FLJ34583") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TMEM17, not a curated reading list.