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TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.
Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.19, genetic association 0.59, somatic mutation 0.93, animal model 0.47).
In plain words · TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.
TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.
Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor.
No product in this corpus aims at TMEM127 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Loftus B.J. et al, Genomics, 1999, "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Source.
Sources: HGNC HGNC:26038 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75204 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135956 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: melanoma 0.51, neuroendocrine neoplasm 0.78 (GraphQL API, CC0))
Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor. Location: Cell membrane; Cytoplasm (UniProt). Locus 2q11.2 (HGNC).
Query for this target: (TITLE:"TMEM127" OR ABSTRACT:"TMEM127" OR TITLE:"transmembrane protein 127" OR ABSTRACT:"transmembrane protein 127" OR TITLE:"Transmembrane protein 127" OR ABSTRACT:"Transmembrane protein 127" OR TITLE:"FLJ20507" OR ABSTRACT:"FLJ20507" OR TITLE:"FLJ22257" OR ABSTRACT:"FLJ22257") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TMEM127, not a curated reading list.