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TLX3 (T-cell leukaemia homeobox protein 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3".
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.16, somatic mutation 0.93).
In plain words · TLX3 (T-cell leukaemia homeobox protein 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
TLX3 (T-cell leukaemia homeobox protein 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3". Location: Nucleus (UniProt).
No product in this corpus aims at TLX3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Delgado et al, 1998, "Genomic characterization of the human and mouse HOX11L2 genes". Source.
Sources: HGNC HGNC:13532 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43711 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164438 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3". Location: Nucleus (UniProt). Locus 5q35.1 (HGNC).
Query for this target: (TITLE:"TLX3" OR ABSTRACT:"TLX3" OR TITLE:"T cell leukemia homeobox 3" OR ABSTRACT:"T cell leukemia homeobox 3" OR TITLE:"T-cell leukemia homeobox protein 3" OR ABSTRACT:"T-cell leukemia homeobox protein 3" OR TITLE:"HOX11L2" OR ABSTRACT:"HOX11L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLX3, not a curated reading list.