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TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.84, somatic mutation 0.95).
In plain words · TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
No product in this corpus aims at TLX1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1991. Earliest sequence paper UniProt cites for the protein: Lu et al, EMBO J, 1991, "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein". Source.
Sources: HGNC HGNC:5056 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31314 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107807 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Location: Nucleus (UniProt). Locus 10q24.31 (HGNC).
Query for this target: (TITLE:"TLX1" OR ABSTRACT:"TLX1" OR TITLE:"T cell leukemia homeobox 1" OR ABSTRACT:"T cell leukemia homeobox 1" OR TITLE:"T-cell leukemia homeobox protein 1" OR ABSTRACT:"T-cell leukemia homeobox protein 1" OR TITLE:"TCL3" OR ABSTRACT:"TCL3" OR TITLE:"HOX11" OR ABSTRACT:"HOX11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLX1, not a curated reading list.