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TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.83, genetic association 0.00).
In plain words · TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane.
No product in this corpus aims at TLN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Mao et al, 1998, "Complete cDNA sequence of human talin". Source.
Sources: HGNC HGNC:11845 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y490 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137076 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. Location: Cell projection, ruffle membrane; Cytoplasm, cytoskeleton; Cell surface; Cell junction, focal adhesion (UniProt). Locus 9p13.3 (HGNC).
Query for this target: (TITLE:"TLN1" OR ABSTRACT:"TLN1" OR TITLE:"talin 1" OR ABSTRACT:"talin 1" OR TITLE:"Talin-1" OR ABSTRACT:"Talin-1" OR TITLE:"ILWEQ" OR ABSTRACT:"ILWEQ") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLN1, not a curated reading list.