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TLK2 (Serine/threonine-protein kinase tousled-like 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Go6983 and GF109203X.
In plain words · TLK2 (Serine/threonine-protein kinase tousled-like 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
TLK2 (Serine/threonine-protein kinase tousled-like 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B.
No product in this corpus aims at TLK2 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Broadly expressed or essential: HPA lists TLK2 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TLK2: RNA low tissue specificity; no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TLK2 tissue; Open Targets ENSG00000146872 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Yamakawa et al, Gene, 1997, "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Source.
Sources: HGNC HGNC:11842 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86UE8 (protein name, function text, keywords and locations (REST API)); CIViC gene TLK2 (1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Location: Nucleus; Nucleus, nucleoplasm; Cytoplasm, perinuclear region; Cytoplasm, cytoskeleton (UniProt). Locus 17q23.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
HPA TLK2 tissue · HPA TLK2 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TLK2" OR ABSTRACT:"TLK2" OR TITLE:"tousled like kinase 2" OR ABSTRACT:"tousled like kinase 2" OR TITLE:"Serine/threonine-protein kinase tousled-like 2" OR ABSTRACT:"Serine/threonine-protein kinase tousled-like 2" OR TITLE:"PKU-ALPHA" OR ABSTRACT:"PKU-ALPHA" OR TITLE:"MGC44450" OR ABSTRACT:"MGC44450") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLK2, not a curated reading list.