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TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.08, somatic mutation 0.79). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.
In plain words · TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.
TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
No product in this corpus aims at TFG yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1995. Earliest sequence paper UniProt cites for the protein: Greco et al, Mol. Cell. Biol, 1995, "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain". Source.
Sources: HGNC HGNC:11758 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92734 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000114354 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: lung cancer 0.51 (GraphQL API, CC0)); IntOGen TFG (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Location: Endoplasmic reticulum (UniProt). Locus 3q12.2 (HGNC).
Query for this target: (TITLE:"TFG" OR ABSTRACT:"TFG" OR TITLE:"trafficking from ER to golgi regulator" OR ABSTRACT:"trafficking from ER to golgi regulator" OR TITLE:"TF6" OR ABSTRACT:"TF6" OR TITLE:"FLJ36137" OR ABSTRACT:"FLJ36137" OR TITLE:"SPG57" OR ABSTRACT:"SPG57") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TFG, not a curated reading list.