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TENT4A (Terminal nucleotidyltransferase 4A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Terminal nucleotidyltransferase that catalyses preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilisation by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.31, affected pathway 0.89, genetic association 0.12).
In plain words · TENT4A (Terminal nucleotidyltransferase 4A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
TENT4A (Terminal nucleotidyltransferase 4A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Terminal nucleotidyltransferase that catalyses preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilisation by protecting mRNAs from active deadenylation.
No product in this corpus aims at TENT4A yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1997. Earliest sequence paper UniProt cites for the protein: Abe et al, 1997, "mLT positive LAK-cell clone No. 1". Source.
Sources: HGNC HGNC:16705 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5XG87 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000112941 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Terminal nucleotidyltransferase that catalyses preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilisation by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. Location: Cytoplasm; Nucleus, nucleoplasm (UniProt). Locus 5p15.31 (HGNC).
Query for this target: (TITLE:"TENT4A" OR ABSTRACT:"TENT4A" OR TITLE:"terminal nucleotidyltransferase 4A" OR ABSTRACT:"terminal nucleotidyltransferase 4A" OR TITLE:"Terminal nucleotidyltransferase 4A" OR ABSTRACT:"Terminal nucleotidyltransferase 4A" OR TITLE:"TRF4" OR ABSTRACT:"TRF4" OR TITLE:"LAK-1" OR ABSTRACT:"LAK-1" OR TITLE:"TRF4-1" OR ABSTRACT:"TRF4-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TENT4A, not a curated reading list.