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TCL1A (T-cell leukaemia/lymphoma protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma, Skin cancer, Diffuse large B-cell lymphoma and 1 more.
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.76, genetic association 0.48, somatic mutation 0.89). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.
In plain words · TCL1A (T-cell leukaemia/lymphoma protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma, Skin cancer, Diffuse large B-cell lymphoma and 1 more.
TCL1A (T-cell leukaemia/lymphoma protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma, Skin cancer, Diffuse large B-cell lymphoma and 1 more.
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1.
No product in this corpus aims at TCL1A yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1994. Earliest sequence paper UniProt cites for the protein: Virgilio et al, Proc. Natl. Acad. Sci. U.S.A, 1994, "Identification of the TCL1 gene involved in T-cell malignancies". Source.
Sources: HGNC HGNC:11648 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P56279 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100721 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.51, non-Hodgkin lymphoma 0.56, skin cancer 0.51 (GraphQL API, CC0)); IntOGen TCL1A (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival. Location: Cytoplasm; Nucleus; Microsome; Endoplasmic reticulum (UniProt). Locus 14q32.13 (HGNC).
Query for this target: (TITLE:"TCL1A" OR ABSTRACT:"TCL1A" OR TITLE:"TCL1 family AKT coactivator A" OR ABSTRACT:"TCL1 family AKT coactivator A" OR TITLE:"T-cell leukemia/lymphoma protein 1A" OR ABSTRACT:"T-cell leukemia/lymphoma protein 1A" OR TITLE:"TCL1" OR ABSTRACT:"TCL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TCL1A, not a curated reading list.