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TBX3 (T-box transcription factor TBX3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Colorectal cancer, Skin cancer and 3 more.
Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation.
Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes affected pathway 0.30, literature 0.98, genetic association 0.73, somatic mutation 0.95, animal model 0.55). IntOGen calls it a driver in 8 cohorts (4 activating, 4 loss-of-function), covering Invasive Breast Carcinoma, Colorectal Adenocarcinoma, Diffuse Large B-Cell Lymphoma, NOS.
In plain words · TBX3 (T-box transcription factor TBX3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Colorectal cancer, Skin cancer and 3 more.
TBX3 (T-box transcription factor TBX3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Colorectal cancer, Skin cancer and 3 more.
Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes.
No product in this corpus aims at TBX3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Bamshad et al, Nat. Genet, 1997, "Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome". Source.
Sources: HGNC HGNC:11602 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15119 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135111 (association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: colorectal cancer 0.62, prostate cancer 0.52, melanoma 0.59, skin cancer 0.59, breast cancer 0.75 (GraphQL API, CC0)); IntOGen TBX3 (driver in 8 cohorts (Act 4, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2. Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signalling. Location: Nucleus (UniProt). Locus 12q24.21 (HGNC).
Query for this target: (TITLE:"TBX3" OR ABSTRACT:"TBX3" OR TITLE:"T-box transcription factor 3" OR ABSTRACT:"T-box transcription factor 3" OR TITLE:"T-box transcription factor TBX3" OR ABSTRACT:"T-box transcription factor TBX3" OR TITLE:"TBX3-ISO" OR ABSTRACT:"TBX3-ISO") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBX3, not a curated reading list.