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TBPL1 (TATA box-binding protein-like 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.64).
In plain words · TBPL1 (TATA box-binding protein-like 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
TBPL1 (TATA box-binding protein-like 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1.
No product in this corpus aims at TBPL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Ohbayashi et al, Biochem. Biophys. Res. Commun, 1999, "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Source.
Sources: HGNC HGNC:11589 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62380 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000028839 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Part of a specialised transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. Location: Cytoplasm; Nucleus (UniProt). Locus 6q23.2 (HGNC).
Query for this target: (TITLE:"TBPL1" OR ABSTRACT:"TBPL1" OR TITLE:"TATA-box binding protein like 1" OR ABSTRACT:"TATA-box binding protein like 1" OR TITLE:"TATA box-binding protein-like 1" OR ABSTRACT:"TATA box-binding protein-like 1" OR TITLE:"TRF2" OR ABSTRACT:"TRF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBPL1, not a curated reading list.