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TAL2 (T-cell acute lymphocytic leukaemia protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
UniProt has no function text for Q16559; HGNC names it "TAL bHLH transcription factor 2".
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.09, animal model 0.50, genetic association 0.07, somatic mutation 0.80). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.
In plain words · TAL2 (T-cell acute lymphocytic leukaemia protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
TAL2 (T-cell acute lymphocytic leukaemia protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
UniProt has no function text for Q16559; HGNC names it "TAL bHLH transcription factor 2". Locus 9q31.2 (HGNC).
No product in this corpus aims at TAL2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1991. Earliest sequence paper UniProt cites for the protein: Xia et al, Proc. Natl. Acad. Sci. U.S.A, 1991, "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Source.
Sources: HGNC HGNC:11557 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16559 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186051 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0)); IntOGen TAL2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for Q16559; HGNC names it "TAL bHLH transcription factor 2". Locus 9q31.2 (HGNC).
Query for this target: (TITLE:"TAL2" OR ABSTRACT:"TAL2" OR TITLE:"TAL bHLH transcription factor 2" OR ABSTRACT:"TAL bHLH transcription factor 2" OR TITLE:"T-cell acute lymphocytic leukemia protein 2" OR ABSTRACT:"T-cell acute lymphocytic leukemia protein 2" OR TITLE:"bHLHa19" OR ABSTRACT:"bHLHa19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TAL2, not a curated reading list.