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STN1 (CST complex subunit STN1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Melanoma.
Component of the CST complex proposed to act as a specialised replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.82, genetic association 0.71, genetic literature 0.76).
In plain words · STN1 (CST complex subunit STN1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Melanoma.
STN1 (CST complex subunit STN1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Melanoma.
Component of the CST complex proposed to act as a specialised replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex.
No product in this corpus aims at STN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:26200 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H668 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107960 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: melanoma 0.52 (GraphQL API, CC0))
Component of the CST complex proposed to act as a specialised replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesised 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. Location: Nucleus; Chromosome, telomere (UniProt). Locus 10q24.33 (HGNC).
Query for this target: (TITLE:"STN1" OR ABSTRACT:"STN1" OR TITLE:"STN1 subunit of CST complex" OR ABSTRACT:"STN1 subunit of CST complex" OR TITLE:"CST complex subunit STN1" OR ABSTRACT:"CST complex subunit STN1" OR TITLE:"FLJ22559" OR ABSTRACT:"FLJ22559" OR TITLE:"bA541N10.2" OR ABSTRACT:"bA541N10.2" OR TITLE:"OBFC1" OR ABSTRACT:"OBFC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STN1, not a curated reading list.