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SRSF3 (Serine/arginine-rich splicing factor 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognises and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.95).
In plain words · SRSF3 (Serine/arginine-rich splicing factor 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SRSF3 (Serine/arginine-rich splicing factor 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing.
No product in this corpus aims at SRSF3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1992. Earliest sequence paper UniProt cites for the protein: Zahler A.M. et al, Genes Dev, 1992, "SR proteins: a conserved family of pre-mRNA splicing factors". Source.
Sources: HGNC HGNC:10785 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P84103 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000112081 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognises and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Location: Nucleus; Nucleus speckle; Cytoplasm (UniProt). Locus 6p21.31-p21.2 (HGNC).
Query for this target: (TITLE:"SRSF3" OR ABSTRACT:"SRSF3" OR TITLE:"serine and arginine rich splicing factor 3" OR ABSTRACT:"serine and arginine rich splicing factor 3" OR TITLE:"Serine/arginine-rich splicing factor 3" OR ABSTRACT:"Serine/arginine-rich splicing factor 3" OR TITLE:"SRp20" OR ABSTRACT:"SRp20" OR TITLE:"SFRS3" OR ABSTRACT:"SFRS3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SRSF3, not a curated reading list.