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SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.95, animal model 0.51, genetic association 0.28).
In plain words · SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
No product in this corpus aims at SPTBN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1992. Earliest sequence paper UniProt cites for the protein: Hu R.J. et al, J. Biol. Chem, 1992, "Characterization of human brain cDNA encoding the general isoform of beta-spectrin". Source.
Sources: HGNC HGNC:11275 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01082 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115306 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. Location: Cytoplasm, cytoskeleton; Cytoplasm, myofibril, sarcomere, M line; Cytoplasm, cytosol; Cell membrane (UniProt). Locus 2p16.2 (HGNC).
Query for this target: (TITLE:"SPTBN1" OR ABSTRACT:"SPTBN1" OR TITLE:"spectrin beta, non-erythrocytic 1" OR ABSTRACT:"spectrin beta, non-erythrocytic 1" OR TITLE:"Spectrin beta chain, non-erythrocytic 1" OR ABSTRACT:"Spectrin beta chain, non-erythrocytic 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SPTBN1, not a curated reading list.