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SNW1 (SNW domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.39, affected pathway 0.95, genetic association 0.03).
In plain words · SNW1 (SNW domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
SNW1 (SNW domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
No product in this corpus aims at SNW1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Folk et al, Gene, 1996, "The homolog of chromatin binding protein Bx42 identified in Dictyostelium". Source.
Sources: HGNC HGNC:16696 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13573 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100603 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 14q24.3 (HGNC).
Query for this target: (TITLE:"SNW1" OR ABSTRACT:"SNW1" OR TITLE:"SNW domain containing 1" OR ABSTRACT:"SNW domain containing 1" OR TITLE:"SNW domain-containing protein 1" OR ABSTRACT:"SNW domain-containing protein 1" OR TITLE:"NCoA-62" OR ABSTRACT:"NCoA-62" OR TITLE:"Prp45" OR ABSTRACT:"Prp45" OR TITLE:"PRPF45" OR ABSTRACT:"PRPF45") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SNW1, not a curated reading list.