Loading
SNTB1 (Beta-1-syntrophin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.71).
In plain words · SNTB1 (Beta-1-syntrophin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SNTB1 (Beta-1-syntrophin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
No product in this corpus aims at SNTB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Ahn A.H. et al, Proc. Natl. Acad. Sci. U.S.A, 1994, "Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24". Source.
Sources: HGNC HGNC:11168 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13884 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000172164 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Location: Cell membrane, sarcolemma; Cell junction; Cytoplasm, cytoskeleton (UniProt). Locus 8q24.12 (HGNC).
Query for this target: (TITLE:"SNTB1" OR ABSTRACT:"SNTB1" OR TITLE:"syntrophin beta 1" OR ABSTRACT:"syntrophin beta 1" OR TITLE:"Beta-1-syntrophin" OR ABSTRACT:"Beta-1-syntrophin" OR TITLE:"59-DAP" OR ABSTRACT:"59-DAP" OR TITLE:"A1B" OR ABSTRACT:"A1B" OR TITLE:"BSYN2" OR ABSTRACT:"BSYN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SNTB1, not a curated reading list.