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SLC6A4 (Sodium-dependent serotonin transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signalling. Essential for serotonin homeostasis in the central nervous system.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.71, animal model 0.28, genetic association 0.00, clinical 0.83).
In plain words · SLC6A4 (Sodium-dependent serotonin transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
SLC6A4 (Sodium-dependent serotonin transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle.
No product in this corpus aims at SLC6A4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SLC6A4: RNA group enriched (intestine 38 nTPM, lung 27 nTPM, placenta 17 nTPM); high antibody staining in 3 normal tissues; highest cancer staining ovarian cancer (1 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SLC6A4 tissue; Open Targets ENSG00000108576 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Lesch K.P. et al, J. Neural Transm, 1993, "Isolation of a cDNA encoding the human brain serotonin transporter". Source.
Sources: HGNC HGNC:11050 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31645 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108576 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signalling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organisation of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signalling at the synapse. Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Location: Cell membrane; Endomembrane system; Endosome membrane; Synapse (UniProt). Locus 17q11.2 (HGNC).
RNA: group enriched (intestine 38 nTPM, lung 27 nTPM, placenta 17 nTPM), detected in some normal tissues.
Medium: Cerebral cortex.
RNA cancer enhanced: Breast Invasive Carcinoma 5 pTPM.
Medium only: cervical cancer, liver cancer, lung cancer.
HPA SLC6A4 tissue · HPA SLC6A4 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SLC6A4" OR ABSTRACT:"SLC6A4" OR TITLE:"solute carrier family 6 member 4" OR ABSTRACT:"solute carrier family 6 member 4" OR TITLE:"Sodium-dependent serotonin transporter" OR ABSTRACT:"Sodium-dependent serotonin transporter" OR TITLE:"5-HTT" OR ABSTRACT:"5-HTT" OR TITLE:"SERT1" OR ABSTRACT:"SERT1" OR TITLE:"OCD1" OR ABSTRACT:"OCD1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC6A4, not a curated reading list.