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SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes genetic literature 0.38, affected pathway 0.76, literature 0.89, genetic association 0.09, somatic mutation 0.71, animal model 0.35).
In plain words · SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
No product in this corpus aims at SLC67A1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Lee M.P. et al, Cancer Res, 1998, "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5". Source.
Sources: HGNC HGNC:10964 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96BI1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110628 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism. Location: Apical cell membrane (UniProt). Locus 11p15.4 (HGNC).
Query for this target: (TITLE:"SLC67A1" OR ABSTRACT:"SLC67A1" OR TITLE:"solute carrier family 67 member 1" OR ABSTRACT:"solute carrier family 67 member 1" OR TITLE:"Solute carrier family 67 member A1" OR ABSTRACT:"Solute carrier family 67 member A1" OR TITLE:"BWR1A" OR ABSTRACT:"BWR1A" OR TITLE:"TSSC5" OR ABSTRACT:"TSSC5" OR TITLE:"IMPT1" OR ABSTRACT:"IMPT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC67A1, not a curated reading list.