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SLC29A1 (Equilibrative nucleoside transporter 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Gemcitabine.
In plain words · SLC29A1 (Equilibrative nucleoside transporter 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
SLC29A1 (Equilibrative nucleoside transporter 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter.
No product in this corpus aims at SLC29A1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA SLC29A1: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 1,049 nTPM); high antibody staining in 6 normal tissues; highest cancer staining thyroid cancer (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Pancreatic ductal adenocarcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas SLC29A1 tissue; Open Targets ENSG00000112759 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Griffiths et al, Nat. Med, 1997, "Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs". Source.
Sources: HGNC HGNC:11003 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99808 (protein name, function text, keywords and locations (REST API)); CIViC gene SLC29A1 (1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Adenocarcinoma (GraphQL API, CC0))
Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Also mediates the uptake of nicotinamide; contributes to maintaining nicotinamide homeostasis but also regulated nicotinamide biological roles. Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier. Location: Basolateral cell membrane; Apical cell membrane; Cell membrane (UniProt). Locus 6p21.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: lineage enriched (granulocytes 1,049 nTPM).
Medium: Appendix, Bronchus, Caudate, Cerebellum, Cerebral cortex, Cervix, Endometrium, Epididymis.
Medium only: breast cancer, carcinoid, cervical cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SLC29A1" OR ABSTRACT:"SLC29A1" OR TITLE:"solute carrier family 29 member 1 Augustine blood group" OR ABSTRACT:"solute carrier family 29 member 1 Augustine blood group" OR TITLE:"Equilibrative nucleoside transporter 1" OR ABSTRACT:"Equilibrative nucleoside transporter 1" OR TITLE:"ENT1" OR ABSTRACT:"ENT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC29A1, not a curated reading list.