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SLC22A3 (Solute carrier family 22 member 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.68).
In plain words · SLC22A3 (Solute carrier family 22 member 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
SLC22A3 (Solute carrier family 22 member 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics.
No product in this corpus aims at SLC22A3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Gruendemann et al, Nat. Neurosci, 1998, "Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter". Source.
Sources: HGNC HGNC:10967 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75751 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000146477 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: prostate cancer 0.54 (GraphQL API, CC0))
Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter. Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency. May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow. Location: Cell membrane; Apical cell membrane; Basolateral cell membrane; Mitochondrion membrane (UniProt). Locus 6q25.3 (HGNC).
Query for this target: (TITLE:"SLC22A3" OR ABSTRACT:"SLC22A3" OR TITLE:"solute carrier family 22 member 3" OR ABSTRACT:"solute carrier family 22 member 3" OR TITLE:"Solute carrier family 22 member 3" OR ABSTRACT:"Solute carrier family 22 member 3" OR TITLE:"OCT3" OR ABSTRACT:"OCT3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC22A3, not a curated reading list.