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SLC14A1 (Urea transporter 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.87, animal model 0.29, genetic association 0.63).
In plain words · SLC14A1 (Urea transporter 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SLC14A1 (Urea transporter 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes.
No product in this corpus aims at SLC14A1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Olives et al, J. Biol. Chem, 1994, "Cloning and functional expression of a urea transporter from human bone marrow cells". Source.
Sources: HGNC HGNC:10918 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13336 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141469 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes. Location: Cell membrane; Basolateral cell membrane (UniProt). Locus 18q12.3 (HGNC).
Query for this target: (TITLE:"SLC14A1" OR ABSTRACT:"SLC14A1" OR TITLE:"solute carrier family 14 member 1 Kidd blood group" OR ABSTRACT:"solute carrier family 14 member 1 Kidd blood group" OR TITLE:"Urea transporter 1" OR ABSTRACT:"Urea transporter 1" OR TITLE:"HsT1341" OR ABSTRACT:"HsT1341" OR TITLE:"RACH1" OR ABSTRACT:"RACH1" OR TITLE:"RACH2" OR ABSTRACT:"RACH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC14A1, not a curated reading list.