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SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Temozolomide and Antisecretory Factor-enriched Egg Yolk Powder Supplement.
In plain words · SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.
No product in this corpus aims at SLC12A2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SLC12A2: RNA tissue enhanced (salivary gland 71 nTPM); high antibody staining in 13 normal tissues; highest cancer staining colorectal cancer (11 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Brain and spinal cord tumours (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SLC12A2 tissue; Open Targets ENSG00000064651 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Payne J.A. et al, J. Biol. Chem, 1995, "Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon". Source.
Sources: HGNC HGNC:10911 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55011 (protein name, function text, keywords and locations (REST API)); CIViC gene SLC12A2 (2 evidence items, 0 assertions, 1 variants; diseases: Glioblastoma (GraphQL API, CC0))
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. Location: Basolateral cell membrane (UniProt). Locus 5q23.3 (HGNC).
RNA: tissue enhanced (salivary gland 71 nTPM), detected in all normal tissues.
Medium: Adrenal gland, Esophagus, Kidney, Liver, Lung, Lymph node, Nasopharynx, Oral mucosa.
RNA cancer enhanced: Colon Adenocarcinoma 114 pTPM, Rectum Adenocarcinoma 104 pTPM.
Medium only: melanoma, renal cancer, skin cancer, testis cancer.
HPA SLC12A2 tissue · HPA SLC12A2 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SLC12A2" OR ABSTRACT:"SLC12A2" OR TITLE:"solute carrier family 12 member 2" OR ABSTRACT:"solute carrier family 12 member 2" OR TITLE:"Solute carrier family 12 member 2" OR ABSTRACT:"Solute carrier family 12 member 2" OR TITLE:"NKCC1" OR ABSTRACT:"NKCC1" OR TITLE:"BSC2" OR ABSTRACT:"BSC2" OR TITLE:"BSC-2" OR ABSTRACT:"BSC-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC12A2, not a curated reading list.