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SKP1 (S-phase kinase-associated protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.83, genetic association 0.00).
In plain words · SKP1 (S-phase kinase-associated protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SKP1 (S-phase kinase-associated protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.
No product in this corpus aims at SKP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Golaz et al, 1994. Source.
Sources: HGNC HGNC:10899 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P63208 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000113558 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signalling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. Locus 5q31.1 (HGNC).
Query for this target: (TITLE:"SKP1" OR ABSTRACT:"SKP1" OR TITLE:"S-phase kinase associated protein 1" OR ABSTRACT:"S-phase kinase associated protein 1" OR TITLE:"S-phase kinase-associated protein 1" OR ABSTRACT:"S-phase kinase-associated protein 1" OR TITLE:"EMC19" OR ABSTRACT:"EMC19" OR TITLE:"OCP2" OR ABSTRACT:"OCP2" OR TITLE:"TCEB1L" OR ABSTRACT:"TCEB1L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SKP1, not a curated reading list.