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SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.85, animal model 0.40, genetic association 0.66).
In plain words · SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
No product in this corpus aims at SIM2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Chen et al, Nat. Genet, 1995, "Single-minded and Down syndrome?". Source.
Sources: HGNC HGNC:10883 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14190 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000159263 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Location: Nucleus (UniProt). Locus 21q22.13 (HGNC).
Query for this target: (TITLE:"SIM2" OR ABSTRACT:"SIM2" OR TITLE:"SIM bHLH transcription factor 2" OR ABSTRACT:"SIM bHLH transcription factor 2" OR TITLE:"Single-minded homolog 2" OR ABSTRACT:"Single-minded homolog 2" OR TITLE:"MGC119447" OR ABSTRACT:"MGC119447" OR TITLE:"bHLHe15" OR ABSTRACT:"bHLHe15") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIM2, not a curated reading list.