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SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.65).
In plain words · SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.
No product in this corpus aims at SIDT1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:25967 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NXL6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000072858 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Location: Membrane (UniProt). Locus 3q13.2 (HGNC).
Query for this target: (TITLE:"SIDT1" OR ABSTRACT:"SIDT1" OR TITLE:"SID1 transmembrane family member 1" OR ABSTRACT:"SID1 transmembrane family member 1" OR TITLE:"FLJ20174" OR ABSTRACT:"FLJ20174" OR TITLE:"SID-1" OR ABSTRACT:"SID-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIDT1, not a curated reading list.