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SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.69, genetic association 0.01, somatic mutation 0.95).
In plain words · SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles.
No product in this corpus aims at SH3GL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Giachino et al, Genomics, 1997, "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Source.
Sources: HGNC HGNC:10830 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99961 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141985 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature. Location: Cytoplasm; Early endosome membrane; Cell projection, podosome (UniProt). Locus 19p13.3 (HGNC).
Query for this target: (TITLE:"SH3GL1" OR ABSTRACT:"SH3GL1" OR TITLE:"SH3 domain containing GRB2 like 1, endophilin A2" OR ABSTRACT:"SH3 domain containing GRB2 like 1, endophilin A2" OR TITLE:"Endophilin-A2" OR ABSTRACT:"Endophilin-A2" OR TITLE:"SH3P8" OR ABSTRACT:"SH3P8" OR TITLE:"SH3D2B" OR ABSTRACT:"SH3D2B" OR TITLE:"CNSA1" OR ABSTRACT:"CNSA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SH3GL1, not a curated reading list.