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SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, animal model 0.54, genetic association 0.14, somatic mutation 0.97).
In plain words · SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.
SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
No product in this corpus aims at SFRP4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Abu-Jawdeh G.M. et al, Lab. Invest, 1999, "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy". Source.
Sources: HGNC HGNC:10778 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6FHJ7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000106483 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: colorectal cancer 0.54, gastric cancer 0.52, skin cancer 0.52 (GraphQL API, CC0))
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signalling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Location: Secreted (UniProt). Locus 7p14.1 (HGNC).
Query for this target: (TITLE:"SFRP4" OR ABSTRACT:"SFRP4" OR TITLE:"secreted frizzled related protein 4" OR ABSTRACT:"secreted frizzled related protein 4" OR TITLE:"Secreted frizzled-related protein 4" OR ABSTRACT:"Secreted frizzled-related protein 4" OR TITLE:"frpHE" OR ABSTRACT:"frpHE" OR TITLE:"FRP-4" OR ABSTRACT:"FRP-4" OR TITLE:"FRPHE" OR ABSTRACT:"FRPHE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SFRP4, not a curated reading list.