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SFPQ (Splicing factor, proline- and glutamine-rich) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner and a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.00, somatic mutation 0.89).
In plain words · SFPQ (Splicing factor, proline- and glutamine-rich) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner and a DNA repair gene, and the evidence so far is association rather than a proven role.
SFPQ (Splicing factor, proline- and glutamine-rich) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner and a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO.
No product in this corpus aims at SFPQ yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Gower H.J. et al, Development, 1989, "Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody". Source.
Sources: HGNC HGNC:10774 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P23246 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000116560 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Location: Nucleus speckle; Nucleus matrix; Cytoplasm (UniProt). Locus 1p34.3 (HGNC).
Query for this target: (TITLE:"SFPQ" OR ABSTRACT:"SFPQ" OR TITLE:"splicing factor proline and glutamine rich" OR ABSTRACT:"splicing factor proline and glutamine rich" OR TITLE:"Splicing factor, proline- and glutamine-rich" OR ABSTRACT:"Splicing factor, proline- and glutamine-rich" OR TITLE:"PPP1R140" OR ABSTRACT:"PPP1R140") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SFPQ, not a curated reading list.