Loading
SDHD (Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.00, somatic mutation 0.96, genetic literature 0.64).
In plain words · SDHD (Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
SDHD (Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
No product in this corpus aims at SDHD yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Hirawake et al, Cytogenet. Cell Genet, 1997, "Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23". Source.
Sources: HGNC HGNC:10683 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14521 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000204370 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.87 (GraphQL API, CC0))
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 11q23.1 (HGNC).
Query for this target: (TITLE:"SDHD" OR ABSTRACT:"SDHD" OR TITLE:"succinate dehydrogenase complex subunit D" OR ABSTRACT:"succinate dehydrogenase complex subunit D" OR TITLE:"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial" OR TITLE:"cybS" OR ABSTRACT:"cybS" OR TITLE:"PGL1" OR ABSTRACT:"PGL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHD, not a curated reading list.