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SDHAF2 (Succinate dehydrogenase assembly factor 2, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Ovarian cancer.
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes literature 0.79, genetic association 0.85, somatic mutation 0.95, genetic literature 0.81).
In plain words · SDHAF2 (Succinate dehydrogenase assembly factor 2, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Ovarian cancer.
SDHAF2 (Succinate dehydrogenase assembly factor 2, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Ovarian cancer.
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.
No product in this corpus aims at SDHAF2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:26034 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NX18 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167985 (association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: ovarian cancer 0.51, neuroendocrine neoplasm 0.83 (GraphQL API, CC0))
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. Location: Mitochondrion matrix (UniProt). Locus 11q12.2 (HGNC).
Query for this target: (TITLE:"SDHAF2" OR ABSTRACT:"SDHAF2" OR TITLE:"succinate dehydrogenase complex assembly factor 2" OR ABSTRACT:"succinate dehydrogenase complex assembly factor 2" OR TITLE:"Succinate dehydrogenase assembly factor 2, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase assembly factor 2, mitochondrial" OR TITLE:"FLJ20487" OR ABSTRACT:"FLJ20487" OR TITLE:"SDH5" OR ABSTRACT:"SDH5" OR TITLE:"PGL2" OR ABSTRACT:"PGL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHAF2, not a curated reading list.