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SCN7A (Sodium channel protein type 7 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behaviour as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.70, genetic association 0.00, clinical 0.86).
In plain words · SCN7A (Sodium channel protein type 7 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
SCN7A (Sodium channel protein type 7 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient.
No product in this corpus aims at SCN7A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SCN7A: RNA tissue enhanced (intestine 33 nTPM, ovary 37 nTPM); no normal tissue stained high; highest cancer staining cervical cancer (1 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SCN7A tissue; Open Targets ENSG00000136546 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: George A.L. Jr. et al, Proc. Natl. Acad. Sci. U.S.A, 1992, "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family". Source.
Sources: HGNC HGNC:10594 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01118 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136546 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behaviour as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body. By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis. Location: Cell membrane (UniProt). Locus 2q24.3 (HGNC).
RNA: tissue enhanced (intestine 33 nTPM, ovary 37 nTPM), detected in many normal tissues.
No normal tissue stained high; medium in Breast, Duodenum, Epididymis, Gallbladder, Heart muscle, Pancreas and more.
Medium only: pancreatic cancer, prostate cancer.
HPA SCN7A tissue · HPA SCN7A pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SCN7A" OR ABSTRACT:"SCN7A" OR TITLE:"sodium voltage-gated channel alpha subunit 7" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 7" OR TITLE:"Sodium channel protein type 7 subunit alpha" OR ABSTRACT:"Sodium channel protein type 7 subunit alpha" OR TITLE:"Nav2.1" OR ABSTRACT:"Nav2.1" OR TITLE:"Nav2.2" OR ABSTRACT:"Nav2.2" OR TITLE:"NaG" OR ABSTRACT:"NaG") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN7A, not a curated reading list.