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SCN10A (Sodium channel protein type 10 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.69, genetic association 0.00, clinical 0.86).
In plain words · SCN10A (Sodium channel protein type 10 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
SCN10A (Sodium channel protein type 10 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes.
No product in this corpus aims at SCN10A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA not detected, which says where the protein sits but not whether the tumour differs from normal tissue. HPA SCN10A: RNA not detected; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas SCN10A tissue; Open Targets ENSG00000185313 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Rabert D.K. et al, Pain, 1998, "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A". Source.
Sources: HGNC HGNC:10582 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5Y9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000185313 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. Location: Cell membrane (UniProt). Locus 3p22.2 (HGNC).
RNA: not detected, not detected normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
HPA SCN10A tissue · HPA SCN10A pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SCN10A" OR ABSTRACT:"SCN10A" OR TITLE:"sodium voltage-gated channel alpha subunit 10" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 10" OR TITLE:"Sodium channel protein type 10 subunit alpha" OR ABSTRACT:"Sodium channel protein type 10 subunit alpha" OR TITLE:"Nav1.8" OR ABSTRACT:"Nav1.8" OR TITLE:"hPN3" OR ABSTRACT:"hPN3" OR TITLE:"PN3" OR ABSTRACT:"PN3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN10A, not a curated reading list.