Loading
SALL4 (Sal-like protein 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.99, animal model 0.29, genetic association 0.41, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.
In plain words · SALL4 (Sal-like protein 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
SALL4 (Sal-like protein 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 2 more.
Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. Location: Cytoplasm; Nucleus (UniProt).
No product in this corpus aims at SALL4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2001. Earliest sequence paper UniProt cites for the protein: Deloukas et al, Nature, 2001, "The DNA sequence and comparative analysis of human chromosome 20". Source.
Sources: HGNC HGNC:15924 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UJQ4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000101115 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, gastric cancer 0.51, melanoma 0.55, skin cancer 0.55 (GraphQL API, CC0)); IntOGen SALL4 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.2 (HGNC).
Query for this target: (TITLE:"SALL4" OR ABSTRACT:"SALL4" OR TITLE:"spalt like transcription factor 4" OR ABSTRACT:"spalt like transcription factor 4" OR TITLE:"Sal-like protein 4" OR ABSTRACT:"Sal-like protein 4" OR TITLE:"dJ1112F19.1" OR ABSTRACT:"dJ1112F19.1" OR TITLE:"ZNF797" OR ABSTRACT:"ZNF797") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SALL4, not a curated reading list.