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RSF1 (Remodeling and spacing factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Tamoxifen.
In plain words · RSF1 (Remodeling and spacing factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
RSF1 (Remodeling and spacing factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair.
No product in this corpus aims at RSF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RSF1: RNA low tissue specificity; high antibody staining in 10 normal tissues; highest cancer staining ovarian cancer (5 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RSF1 tissue; Open Targets ENSG00000048649 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Mao Y.M. et al, 1998. Source.
Sources: HGNC HGNC:18118 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96T23 (protein name, function text, keywords and locations (REST API)); CIViC gene RSF1 (1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively. The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex. The complexes do not have the ability to slide mononucleosomes to the centre of a DNA template. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. Location: Nucleus (UniProt). Locus 11q14.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bone marrow, Breast, Bronchus, Cervix, Colon, Duodenum.
Medium only: liver cancer, lymphoma, pancreatic cancer, prostate cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RSF1" OR ABSTRACT:"RSF1" OR TITLE:"remodeling and spacing factor 1" OR ABSTRACT:"remodeling and spacing factor 1" OR TITLE:"Remodeling and spacing factor 1" OR ABSTRACT:"Remodeling and spacing factor 1" OR TITLE:"XAP8" OR ABSTRACT:"XAP8" OR TITLE:"RSF-1" OR ABSTRACT:"RSF-1" OR TITLE:"p325" OR ABSTRACT:"p325") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RSF1, not a curated reading list.