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RPS7 (Small ribosomal subunit protein eS7) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes genetic literature 0.76, clinical 0.11, literature 0.90, genetic association 0.04, animal model 0.35).
In plain words · RPS7 (Small ribosomal subunit protein eS7) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
RPS7 (Small ribosomal subunit protein eS7) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
No product in this corpus aims at RPS7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists RPS7 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS7: RNA low tissue specificity; high antibody staining in 31 normal tissues; highest cancer staining endometrial cancer (10 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RPS7 tissue; Open Targets ENSG00000171863 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Annilo et al, Gene, 1995, "The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25". Source.
Sources: HGNC HGNC:10440 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62081 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171863 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm; Nucleus, nucleolus (UniProt). Locus 2p25.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Gallbladder, Heart muscle, Kidney, Liver, Lung, Lymph node, Ovary.
Medium only: head and neck cancer, liver cancer, lung cancer, melanoma.
HPA RPS7 tissue · HPA RPS7 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPS7" OR ABSTRACT:"RPS7" OR TITLE:"ribosomal protein S7" OR ABSTRACT:"ribosomal protein S7" OR TITLE:"Small ribosomal subunit protein eS7" OR ABSTRACT:"Small ribosomal subunit protein eS7" OR TITLE:"S7" OR ABSTRACT:"S7" OR TITLE:"eS7" OR ABSTRACT:"eS7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS7, not a curated reading list.