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ROBO4 (Roundabout homolog 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organisation and function.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Angiogenesis Inhibitor.
In plain words · ROBO4 (Roundabout homolog 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
ROBO4 (Roundabout homolog 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins.
No product in this corpus aims at ROBO4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ROBO4: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ROBO4 tissue; Open Targets ENSG00000154133 associations
First described 2002. Earliest sequence paper UniProt cites for the protein: Huminiecki et al, Genomics, 2002, "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis". Source.
Sources: HGNC HGNC:17985 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WZ75 (protein name, function text, keywords and locations (REST API)); CIViC gene ROBO4 (1 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0))
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organisation and function. Locus 11q24.2 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Kidney Renal Clear Cell Carcinoma 33 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ROBO4" OR ABSTRACT:"ROBO4" OR TITLE:"roundabout guidance receptor 4" OR ABSTRACT:"roundabout guidance receptor 4" OR TITLE:"Roundabout homolog 4" OR ABSTRACT:"Roundabout homolog 4" OR TITLE:"FLJ20798" OR ABSTRACT:"FLJ20798" OR TITLE:"ECSM4" OR ABSTRACT:"ECSM4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ROBO4, not a curated reading list.