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RNF6 (E3 ubiquitin-protein ligase RNF6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Oesophageal cancer.
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.08, somatic mutation 0.66, genetic literature 0.30). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.
In plain words · RNF6 (E3 ubiquitin-protein ligase RNF6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Oesophageal cancer.
RNF6 (E3 ubiquitin-protein ligase RNF6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Oesophageal cancer.
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover.
No product in this corpus aims at RNF6 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Macdonald D.H.C. et al, Genomics, 1999, "Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12". Source.
Sources: HGNC HGNC:10069 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y252 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000127870 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: oesophageal cancer 0.51 (GraphQL API, CC0)); IntOGen RNF6 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Mediates polyubiquitination of QKI in macrophages, leading to its degradation. Location: Nucleus; Cytoplasm; Cell projection, axon; Nucleus, PML body (UniProt). Locus 13q12.13 (HGNC).
Query for this target: (TITLE:"RNF6" OR ABSTRACT:"RNF6" OR TITLE:"ring finger protein 6" OR ABSTRACT:"ring finger protein 6" OR TITLE:"E3 ubiquitin-protein ligase RNF6" OR ABSTRACT:"E3 ubiquitin-protein ligase RNF6" OR TITLE:"DKFZp686P0776" OR ABSTRACT:"DKFZp686P0776") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RNF6, not a curated reading list.