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RMI1 (RecQ-mediated genome instability protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.44, affected pathway 0.87, genetic association 0.39).
In plain words · RMI1 (RecQ-mediated genome instability protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
RMI1 (RecQ-mediated genome instability protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.
No product in this corpus aims at RMI1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:25764 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H9A7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178966 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. Location: Nucleus (UniProt). Locus 9q21.32 (HGNC).
Query for this target: (TITLE:"RMI1" OR ABSTRACT:"RMI1" OR TITLE:"RecQ mediated genome instability 1" OR ABSTRACT:"RecQ mediated genome instability 1" OR TITLE:"RecQ-mediated genome instability protein 1" OR ABSTRACT:"RecQ-mediated genome instability protein 1" OR TITLE:"FLJ12888" OR ABSTRACT:"FLJ12888" OR TITLE:"BLAP75" OR ABSTRACT:"BLAP75" OR TITLE:"C9orf76" OR ABSTRACT:"C9orf76") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RMI1, not a curated reading list.